Janeen H. Trembley, PhD - Minneapolis VA Health Care System
Attention A T users. To access the menus on this page please perform the following steps. 1. Please switch auto forms mode to off. 2. Hit enter to expand a main menu option (Health, Benefits, etc). 3. To enter and activate the submenu links, hit the down arrow. You will now be able to tab or arrow up or down through the submenu options to access/activate the submenu links.

Minneapolis VA Health Care System

Menu
Menu
Veterans Crisis Line Badge
My HealtheVet badge
EBenefits Badge
 

Janeen H. Trembley, PhD

Dr. Janeen Trembley

Research Chemist, Minneapolis VA Health Care System

Assistant Professor, Laboratory Medicine Pathology, University of Minnesota

Telephone: 612-467-2877

Email: janeen.trembley@va.gov

 

 

Education

  • BA, Grinnell College, Grinnell, IA
  • PhD, University of Minnesota

Research Interests

  • CK2 and CDK11 signaling
  • Breast cancer
  • Prostate cancer
  • Molecular approaches to cancer therapy

Selected Publications

  • Trembley JH, Unger G, Korman VL, Tobolt DK, Kazimierczuk Z, Pinna LA, Kren BT, Ahmed K. Nanoencapsulated anti-CK2 small molecule drug or siRNA specifically targets malignant cancer but not benign cells. Cancer Letters 315:48-58, 2012.
  • Unger G., Trembley J., Kren B, Ahmed K.: Nanoparticles in Cancer Therapy. In: Schwab M. (Ed.) Encyclopedia of Cancer: SpringerReference (www.springerreference.com). Springer-Verlag Berlin Heidelberg. DOI: 10.1007/SpringerReference_175620 2012-03-05 10:28:01 UTC 2012.
  • Trembley JH, Unger G, Tobolt DK, Korman VL, Wang G, Ahmad KA, Slaton JW, Kren BT, Ahmed K. Systemic administration of antisense oligonucleotides simultaneously targeting CK2a and a′ subunits reduces orthotopic xenograft prostate tumors in mice. Molecular and Cellular Biochemistry 356:21-35, 2011.
  • Trembley JH, Chen Z, Unger G, Slaton J, Kren BT, Van Waes C, Ahmed K. Emergence of Protein Kinase CK2 as a Key Target in Cancer Therapy. BioFactors 36:187-195, 2010.
  • Loyer P, Trembley JH, Grenet JA, Busson A, Corlu A, Zhao W, Kocak M, Kidd VJ, Lahti JM. Characterization of Cyclin L1 and L2 interactions with CDK11 and splicing factors to regulate pre-mRNA splicing: Influence of cyclin L isoforms on splice site selection. Journal of Biological Chemistry 238:7721-7732, 2008.
  • Trembley JH, Tatsumi S, Sakashita E, Loyer P, Slaughter CA, Suzuki H, Endo H, Kidd VJ, Mayeda A. Activation of pre-mRNA splicing by human RNPS1 is regulated by CK2 phosphorylation. Molecular and Cellular Biology 25:1446-1457, 2005.
  • Trembley JH, Hu D, Slaughter CA, Lahti JM, Kidd VJ. CK2 interacts with CDK11 in vivo and phosphorylates both the RNAP II CTD and CDK11 in vitro. Journal of Biological Chemistry 278:2265-2270, 2003.

 

Back
return to top go