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Minneapolis VA Health Care System

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Karen H. Ashe, MD, PhD

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Staff Physician, Minneapolis VA Health Care System

Director, N. Bud Grossman Center for Memory Research, University of Minnesota

Professor, Neurology, University of Minnesota

Phone: 612-467-4770

Email: karen.ashe@va.gov

 

Education

  • AB, Harvard University, Cambridge, MA
  • PhD, Harvard University, Cambridge, MA
  • MD, Harvard Medical School, Boston, MA

Research Interests

  • Molecular biology of prion diseases
  • Alzheimer's Disease

Selected Publications

  • Ashe, KH and Zahs, KR. Probing the biology of Alzheimer's disease in mice. Neuron 66:631-45, 2010.
  • Zahs, KR and Ashe, KH. "Too much good news!" Are Alzheimer mouse models trying to tell us how to prevent, not cure, Alzheimer's disease? Trends in Neurosciences 33: 381-389, 2010.
  • Lesné, S., Kotilinek, L., & Ashe, K. H. (2008). Plaque-bearing mice with reduced levels of oligomeric amyloid-β assemblies have intact memory function. Neuroscience, 151(3), 745-749.
  • Kotilinek, L. A., Westerman, M. A., Wang, Q., Panizzon, K., Lim, G. P., Simonyi, A., ... & Ashe, K. H. (2008). Cyclooxygenase-2 inhibition improves amyloid-β-mediated suppression of memory and synaptic plasticity. Brain, 131(3), 651-664.
  • Ma, H., Lesné, S., Kotilinek, L., Steidl-Nichols, J. V., Sherman, M., Younkin, L., ... & Ashe, K. H. (2007). Involvement of β-site APP cleaving enzyme 1 (BACE1) in amyloid precursor protein-mediated enhancement of memory and activity-dependent synaptic plasticity. Proceedings of the National Academy of Sciences, 104(19), 8167-8172.
  • Lesné, S., Koh, M. T., Kotilinek, L., Kayed, R., Glabe, C. G., Yang, A., ... & Ashe, K. H. (2006). A specific amyloid-β protein assembly in the brain impairs memory. Nature, 440(7082), 352-357.
  • Santacruz, K., Lewis, J., Spires, T., Paulson, J., Kotilinek, L., Ingelsson, M., ... & Ashe, K. H. (2005). Tau suppression in a neurodegenerative mouse model improves memory function. Science, 309(5733), 476-481.
  • Ramsden, M., Kotilinek, L., Forster, C., Paulson, J., McGowan, E., SantaCruz, K., ... & Ashe, K. H. (2005). Age-dependent neurofibrillary tangle formation, neuron loss, and memory impairment in a mouse model of human tauopathy (P301L). The journal of neuroscience, 25(46), 10637-10647.
  • Cleary, J. P., Walsh, D. M., Hofmeister, J. J., Shankar, G. M., Kuskowski, M. A., Selkoe, D. J., & Ashe, K. H. (2005). Natural oligomers of the amyloid-β protein specifically disrupt cognitive function. Nature neuroscience, 8(1), 79-84.
  • Westerman, M. A., Cooper-Blacketer, D., Mariash, A., Kotilinek, L., Kawarabayashi, T., Younkin, L. H., ... & Ashe, K. H. (2002). The relationship between Aβ and memory in the Tg2576 mouse model of Alzheimer's disease. The Journal of neuroscience, 22(5), 1858-1867.
  • Kotilinek, L. A., Bacskai, B., Westerman, M., Kawarabayashi, T., Younkin, L., Hyman, B. T., ... & Ashe, K. H. (2002). Reversible memory loss in a mouse transgenic model of Alzheimer's disease. The Journal of neuroscience, 22(15), 6331-6335.
  • Kawarabayashi, T., Younkin, L. H., Saido, T. C., Shoji, M., Ashe, K. H., & Younkin, S. G. (2001). Age-dependent changes in brain, CSF, and plasma amyloid β protein in the Tg2576 transgenic mouse model of Alzheimer's disease. The Journal of Neuroscience, 21(2), 372-381.
  • Lim, G. P., Yang, F., Chu, T., Chen, P., Beech, W., Teter, B., ... & Cole, G. M. (2000). Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease. The journal of Neuroscience, 20(15), 5709-5714.
  • Chapman, P. F., White, G. L., Jones, M. W., Cooper-Blacketer, D., Marshall, V. J., Irizarry, M., ... & Hsiao, K. K. (1999). Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice. Nature neuroscience, 2(3), 271-276.
  • Holcomb, L., Gordon, M. N., McGowan, E., Yu, X., Benkovic, S., Jantzen, P., ... & Duff, K. (1998). Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes. Nature medicine, 4(1), 97-100.
    • ,li>Hsiao, K. K., Borchelt, D. R., Olson, K., Johannsdottir, R., Kitt, C., Yunis, W., ... & Carlson, G. (1995). Age-related CNS disorder and early death in transgenic FVB/N mice overexpressing Alzheimer amyloid precursor proteins. Neuron, 15(5), 1203-1218.
  • Hsiao, K. K., Scott, M., Foster, D., GRoTH, D. F., Dearmond, S. J., & Prusiner, S. B. (1990). Spontaneous neurodegeneration in transgenic mice with mutant prion protein. Science, 250(4987), 1587-1590.
  • Hsiao, K., Baker, H. F., Crow, T. J., Poulter, M., Owen, F., Terwilliger, J. D., ... & Prusiner, S. B. (1989). Linkage of a prion protein missense variant to Gerstmann–Sträussler syndrome. Nature, 338(6213), 342-345.

 

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